40 Powerful Prayers Against the Spirit of Infirmity

The battle against sickness is not just physical—it’s spiritual too. Many people face recurring illnesses that doctors can’t explain or heal. In such cases, prayer becomes a mighty weapon. If you’re dealing with persistent health issues, these prayers against the spirit of infirmity will guide you in asking God for healing, deliverance, and restoration.

What is the Spirit of Infirmity?

The spirit of infirmity is a demonic force responsible for prolonged sickness, weakness, and physical afflictions. In Luke 13:11, Jesus healed a woman who had been crippled for 18 years due to a spirit of infirmity. This wasn’t just a medical condition—it was a spiritual bondage.

This spirit can manifest in many ways:

• Chronic pain or illness with no medical diagnosis
• Constant fatigue
• Generational health issues
• Unexplained deterioration in physical condition
• Health setbacks right after progress

Identifying this spirit is the first step. The next step is using targeted prayer to break its hold and claim complete healing through Jesus Christ.

40 Powerful Prayers Against the Spirit of Infirmity

Here are 40 powerful prayers against the spirit of infirmity that you can pray:

1. Heavenly Father, I come before You in the name of Jesus, rebuking every spirit of infirmity attacking my body. By the stripes of Jesus, I declare my healing and complete restoration. Amen.
2. Lord, Your Word says You are the God who heals me. I stand on that promise today and command every sickness and disease to leave my body now in Jesus’ name.
3. Father God, I break every curse of infirmity over my life. I cancel every assignment of the enemy against my health and declare divine wholeness in every part of my being.
4. Jesus, You bore my sicknesses and carried my pains. I receive Your finished work on the cross and reject every symptom of infirmity in my body.
5. Holy Spirit, fill me with Your healing power. Let Your life flow through every cell, tissue, and organ in my body, driving out all weakness and disease.
6. Lord, I renounce every legal right the enemy has over my health. I plead the blood of Jesus over my body and command every infirmity to flee!
7. Father, just as You healed the woman with the issue of blood, stretch forth Your healing hand upon me now. Let Your virtue restore me completely.
8. Mighty God, I silence every voice of infirmity speaking lies over my body. I decree that my body aligns with Your Word—healthy, strong, and full of life!
9. Jesus, You are the Resurrection and the Life. I speak life to every dead area in my body and command it to function as You designed.
10. Lord of Hosts, dispatch Your warring angels to fight against every spirit of infirmity attacking me. Let them be bound and cast out in Jesus’ name!
11. Father, I reject every generational sickness passed down in my family line. I break its power over me and receive my divine health inheritance.
12. Healing Savior, just as You spoke to the storm and it obeyed, speak peace to every raging sickness in my body and let it cease now!
13. Lord, I cancel every demonic diagnosis and prognosis over my life. I declare that no weapon of infirmity formed against me shall prosper.
14. Jesus, Your Word is medicine to my flesh. I feed on Your promises and command every symptom contrary to Your will to disappear.
15. Almighty God, I resist the spirit of infirmity with the shield of faith. I refuse to accept sickness as my portion—I walk in divine health!
16. Father, let Your healing fire consume every root of disease in my body. Burn away all infections, inflammations, and malfunctions now!
17. Lord Jesus, by Your authority, I command every pain, swelling, and abnormal growth to dry up and die at its roots in Your mighty name.
18. Heavenly Physician, perform a supernatural surgery on my body. Remove every trace of sickness and restore me to perfect health.
19. God of Miracles, breathe upon my body right now. Let Your breath of life destroy every infirmity and revive every weakened area.
20. Father, I loose myself from every demonic grip of chronic illness. I declare that my body is the temple of the Holy Spirit, and sickness has no place here!
21. Jesus, just as You healed the paralytic, stretch forth Your hand and restore strength to every weak part of my body.
22. Lord, I silence every lying symptom that contradicts Your Word. I stand firm on Your promise that I am healed by Your stripes!
23. Merciful God, uproot every hidden cause of infirmity in my body. Expose and destroy every hidden sickness in Jesus’ name.
24. Father, I command every organ and system in my body to function perfectly according to Your divine design. No more malfunction or failure!
25. Jesus, I apply Your blood over my body as a shield against every attack of infirmity. Sickness cannot dwell where Your blood covers!
26. Lord, I break every soul tie with sickness. I refuse to partner with pain, disease, or weakness—I embrace Your wholeness!
27. Heavenly Father, let Your healing light penetrate every dark area of sickness in my body. Dispel all darkness and restore vitality!
28. Jesus, You are the same yesterday, today, and forever. Just as You healed in the Bible, heal me now—I receive my miracle!
29. Lord, I cancel every demonic transaction bringing infirmity into my life. I nullify every evil covenant and declare my freedom!
30. Father, I speak to my bones, muscles, nerves, and blood—be restored, rejuvenated, and revitalized in Jesus’ mighty name!
31. Jesus, I reject every spirit of fear and death attached to my sickness. I declare that I will live and not die to declare Your works!
32. Lord, let Your healing anointing flow like a river through my body, washing away every trace of infirmity and disease.
33. Father, I command every malfunctioning cell to come into divine order. Let there be perfect alignment with Your health in me!
34. Jesus, I stand against every autoimmune attack on my body. I speak peace to my immune system and command it to function perfectly.
35. Lord, I break every hex, jinx, or curse of infirmity sent against me. I reverse it now by the power in the blood of Jesus!
36. Heavenly Father, I pull down every stronghold of sickness in my life. I declare that my body is under Your dominion, not disease!
37. Jesus, I command every viral, bacterial, and fungal infection to die now. My body is cleansed and purified by Your power!
38. Lord, I release my faith for total healing. I refuse to doubt—I believe that right now, my body is being restored!
39. Father, I thank You for my healing before I see it fully manifest. I praise You for victory over every spirit of infirmity!
40. Jesus, I seal these prayers with Your name. I walk in divine health from this moment forward, glorifying You all the days of my life. Amen!

Conclusion

The spirit of infirmity may try to bind you in cycles of sickness, but you have authority through Jesus Christ to reject and defeat it. These prayers are not magic formulas—they are declarations of faith. Consistent, faith-filled prayer backed by the Word of God has the power to break any spiritual chain.

If you’ve been struggling with chronic illness, don’t give up. Stand firm in prayer. Speak life over your body. Believe that your healing has already begun.